Entities unleashed in The Adventure of the Deadly Dimensions continue to leak into the human realm and enter human minds, altering their neurochemistry. Two of the victims are Dr. Watson and the leader of the cult, Prof. Henry Fitzgerald who seeks to use human sacrifice to open wide the door to the Old Ones.
As psychotic violence erupts in London, Holmes secludes himself in the Diogenes Club and uses his chemical mastery to develop an antidote to counter the neural psychoses. As Moriarty uses the drug to amass an army of addicts, Holmes discovers a link to a town in America. Innsmouth.
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